CapiScope, CAM1 Capillary Anemometer, HVCS and VCS Video Capillaroscopy System References

Skin capillary density changes in normal pregnancy and pre-eclampsia. Journal of Hypertension. 20(12):2439-2443, December 2002. Hasan, Khaled M a; Manyonda, Isaac T b; Ng, Fu Siong a; Singer, Donald RJ a; Antonios, Tarek FT Link

Clinical Science (1999) 97, (523–528) (Printed in Great Britain) Maximization of skin capillaries during intravital video-microscopy in essential hypertension: comparison between venous congestion, reactive hyperaemia and core heat load tests Tarek F. T. ANTONIOS, Fraser E. M. RATTRAY, Donald R. J. SINGER, Nirmala D. MARKANDU, Peter S. MORTIMER‡ and Graham A. MACGREGOR Link

(Hypertension. 1999;34:655-658.) Scientific Contributions Rarefaction of Skin Capillaries in Borderline Essential Hypertension Suggests an Early Structural Abnormality Tarek F. T. Antonios; Donald R. J. Singer; Nirmala D. Markandu; Peter S. Mortimer; Graham A. MacGregor Link

Heart. 2003 Feb;89(2):175-8. Rarefaction of skin capillaries in normotensive offspring of individuals with essential hypertension. Antonios TF, Rattray FM, Singer DR, Markandu ND, Mortimer PS, MacGregor GA. Link

Antonios TFT. State of the art review: Clinical microcirculatory studies in hypertension. Microcirculation in Cardiovascular Disease 2003 ; 5: 4 – 14.

Antonios TFT, Rattray FM, Markandu ND, MacGregor GA. Rarefaction of skin capillaries in normotensive offspring of individuals with essential hypertension suggests a primary vascular abnormality. Cardiovascular Journal 2003 ; 1: 24 – 26.

ORSOLYA GENZEL-BOROVICZÉNY, FRANK CHRIST and VERENA GLAS. Blood Transfusion Increases Functional Capillary Density in the Skin of Anemic Preterm Infants. Pediatric Research 56:751-755 (2004) Link

Microangiopathy in Chronic Venous Insufficiency: Quantitative Assessment by Capillary Microscopy . European Journal of Vascular and Endovascular Surgery , Volume 26 , Issue 3 , Pages 325 - 331 M . Howlader Link

Impaired 0.1-Hz vasomotion assessed by laser Doppler anemometry as an early index of peripheral sympathetic neuropathy in diabetes M. F. Meyer, C. J. Rose, J. -O. Hülsmann, H. Schatz and M. Pfohl Department of Internal Medicine, University Clinic Bergmannsheil, Ruhr-University Bochum, D-44789, Bochum, Germany Link

Correlation of severity of chronic venous disease with capillary morphology assessed by capillary microscopy . Journal of Vascular Surgery , Volume 43 , Issue 3 , Pages 563 - 569 M . Howlader , P . Smith Link

Lack of a difference in increased capillary blood cell velocity in the skin over proximal interphalangeal joints between rheumatoid arthritis and osteoarthritis M.F. Meyer, H. Czaplewski, J. Braun, B. Hellmich, H. Schatz and H.H. Klein Link

HVCS

Automated measurement of microvascular function reveals dysfunction in systemic sclerosis: a cross-sectional study: Machin, Daniel R. and Gates, Phillip E. and Vink, Hans and Frech, Tracy M. and Donato, Anthony J. Google Scholar
The Role of Genetically Modified Mesenchymal Stem Cells in Urinary Bladder Regeneration.: Snow-Lisy, Devon C and Diaz, Edward C and Bury, Matthew I and Fuller, Natalie J and Hannick, Jessica H and Ahmad, Nida and Sharma, Arun K DOI Link PubMed Link Google Scholar
Microvascular imaging: techniques and opportunities for clinical physiological measurements.: Allen, John and Howell, Kevin DOI Link PubMed Link Google Scholar
Sublingual microcirculation in pulmonary arterial hypertension.: Dababneh, Luma and Cikach, Frank and Alkukhun, Laith and Dweik, Raed A and Tonelli, Adriano R DOI Link PubMed Link Google Scholar
Functional capillary impairment in patients with ventricular assist devices: Patricia P. Wadowski 1 , Barbara Steinlechner 2 , Daniel Zimpfer 3 , Thomas Schlöglhofer 3,4,5 , Heinrich Schima 4,5 , Martin Hülsmann 6 , Irene M. Lang 6 , Thomas Gremmel 1 , Renate Koppensteiner 1 , Sonja Zehetmayer 7 , Constantin Weikert 1 , Joseph Pultar 1 & Bernd Jilma Scientific Reports (2019) 9:5909 https://doi.org/10.1038/s41598-019-42334-3
Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion: Tracey L. Weissgerber, PhD; Oscar Garcia-Valencia, MD; Natasa M. Milic, MD, PhD; Elizabeth Codsi, MD; Hajrunisa Cubro, MD; Meryl C. Nath, BA; Wendy M. White, MD; Karl A. Nath, MD; Vesna D. Garovic, MD, PhD J Am Heart Assoc. 2019;8:e010647. DOI: 10.1161/JAHA.118.010647
Sidestream Dark Field (SDF) imaging of oral microcirculation in the assessment of systemic sclerosis: M. Sha, M. Griﬃn , C.P. Denton, P.E. Butler https://doi.org/10.1016/j.mvr.2019.103890
Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study: Alexandros Rovas 1 , Jan Sackarnd 2 , Jan Rossaint 3 , Stefanie Kampmeier 4 , Hermann Pavenstädt 1 , Hans Vink 5† and Philipp Kümpers 1†* Crit Care (2021) 25:112 https://doi.org/10.1186/s13054-021-03520-w

CAM1

Morris S J, Kunzek S, Shore A C. (1996) The effect of acetylcholine on finger capillary pressure and capillary flow in healthy volunteers Journal of Physiology (1996), 494.1, pp 307-313. PDF

Stücker M, Baier V, Reuther T, Hoffmann K, Kellam K, Altmeyer P. (1996) Capillary Blood Cell Velocity in Human Skin Capillaries Located Perpendicularly to the Skin Surface: Measured by a new Laser Doppler Anemometer Microvascular Research 52, pp 188-192. PDF

Altmeyer P., Hoffmann K., Stücker 'Kutane Mikrozirkulation', Springer, ISBN 3-540-62564-X, pp 188-199. link

MEASUREMENT OF THE RED BLOOD CELL VELOCITY IN CAPILLARIES OF THE MEDIAL ANKLE IN PATIENTS WITH ACUTE DEEP VEIN THROMBOSIS BY MEANS OF A LASER-DOPPLER-ANEMOMETER M. SPIEGEL, C. KUHLI, A. PIRA, E. LINDHOFF-LAST, A. M. 20th European Conference on Microcirculation Paris 1998

VALIDATION OF VELOCITY MEASUREMENTS IN HUMAN NAIL FOLD CAPILLARIES BY MEANS OF A LASER-DOPPLER-ANEMOMETER IN DIRECT COMPARISON WITH THE FRAME TO FRAME METHOD M. Spiegel, C. Kuhli, I. Spiegel, A. M. Ehrly. 20th European Conference on Microcirculation Paris 1998

VELOCITY MEASUREMENT IN CAPILLARIES OF THE HUMAN SKIN DURING APPLICATION OF NICOTINE BLASTERS M. Spiegel, A. Pira, E. Lindhoff-Last, A. M. Ehrly. 20th European Conference on Microcirculation Paris 1998

INFLUENCE OF METABOLIC CONTROL AND DURATION OF DISEASE ON MICROVASCULAR DYSFUNCTION IN DIABETES ASSESSED BY LASER DOPPLER ANEMOMETRY M.F. Meyer and H. Schatz. 34th general Assembly of the European Association for the Study of Diabetes, Barcelona, Spain 1998. See

INFLUENCE OF METABOLIC CONTROL AND DURATION OF DISEASE ON MICROVASCULAR DYSFUNCTION IN DIABETES ASSESSED BY LASER DOPPLER ANEMOMETRY M.F. Meyer and H. Schatz. Exp Clin Endocrinol Diabetes 106 (1998) 395-403. PDF

CAPILLARY MORPHOLOGY OF PATIENTS WITH CHRONIC VENOUS DISEASE OF LOWER LIMB Mr. M.H. Howlader, Mr. P.D. Coleridge Smith. British Microcirculation Society Scientific Meeting 2001 See

VALIDATION OF MEASUREMENTS IN CAPILLARY BLOOD FLOW BY MEANS OF LASER DOPPLER CAPILLAROMETER (ANEMOMETER) G.Madycki, W.Staszkiewicz, W.Hendiger, P.Slowinski 21st European Conference on Microcirculation 4-7 June 2000 Stockholm See

THE EFFECT OF SKIN COMPRESSION ON CAPILLARY BLOOD VELOCITY IN PATIENTS WITH COMBINED ARTERIAL & VENOUS DISEASE S S Shoab, M Howlader, P D Coleridge-Smith 7th World Congress for Microcirculation 19-22 August 2001 Sydney, Australia See

Endothelial dysfunction, microvascular damage and ischemic peripheral vasculopathy in systemic sclerosis: da Silva, Ivone Fernandes Santos and Teixeira, Andreia and Oliveira, José and Almeida, Rui and Vasconcelos, Carlos Google Scholar
Effects of candesartan versus amlodipine on capillary rarefaction, pulse wave velocity, and central blood pressure in patients with essential hypertension: Raghuraman, R. and Carney, C. and Mullahy, H. and Ogunseitan, O. and Wang, Duolao and Antonios, T. F. T. DOI Link Google Scholar
Digital ulcers in systemic sclerosis: role of flow-mediated dilatation and capillaroscopy as risk assessment toolsDigital ulcers in patients with systemic sclerosis: Silva, Ivone and Loureiro, Tiago and Teixeira, Andreia and Almeida, Isabel and Mansilha, Armando and Vasconcelos, Carlos and Almeida, Rui Google Scholar
The skin microcirculatory changes in the normal and hypertensive elderly: El Nahid, M. S. and El Ashmaui, A. Google Scholar
Pulsed electromagnetic field therapy promotes healing and microcirculation of chronic diabetic foot ulcers: a pilot study: Kwan, Rachel Lai-Chu and Wong, Wing-Cheung and Yip, Siu-Leung and Chan, Ka-Lun and Zheng, Yong-Ping and Cheing, Gladys Lai-Ying Google Scholar
Microvascular imaging: techniques and opportunities for clinical physiological measurements.: Allen, John and Howell, Kevin DOI Link PubMed Link Google Scholar
THE STRUCTURAL AND FUNCTIONAL ABNORMALITIES IN THE SKIN MICROCIRCULATION OF EGYPTIAN PATIENTS WITH LONG STANDING DIABETES.: El-Nahid, Maggie S. and Ashmaui, Aly El Google Scholar
Functional and structural abnormalities of the skin microcirculation in hemodialysis patients: El-Nahid, Maggie S. and El-Ashmaoui, Ali M. and others, DOI Link Google Scholar
Modern scientific explanation of traditional acupuncture theory: Hsieh, Ching-Liang Google Scholar
Non-invasive linear polarized light irradiation on the stellate ganglion improves skin blood flow in patients with Blackfoot Disease: Lee, C. H. and Yu, H. S. Google Scholar
Qualitative and quantitative assessment of nailfold capillaries by capillaroscopy in healthy volunteers: Hoerth, Christian and Kundi, Michael and Katzenschlager, Reinhold and Hirschl, Mirko Google Scholar
Capillary remodelling in normal pregnancy: Can it mediate the progressive but reversible rise in blood pressure? Novel insights into cardiovascular adaptation in pregnancy: Nama, Vivek and Antonios, Tarek F. and Onwude, Joseph and Manyonda, Isaac T. Google Scholar
Immediate effects of monochromatic infrared energy on microcirculation in healthy subjects: Mak, Michael CH and Cheing, Gladys LY DOI Link Google Scholar
Effects of a short-term improvement in glycaemic control on skin microvascular dysfunction in Type 1 and Type 2 diabetic patients: Meyer, M. F. and Rose, C. J. and Schatz, H. and Klein, H. H. DOI Link Google Scholar
Microvascular dysfunction in rheumatoid arthritis assessed by laser Doppler anemometry: relationship to soluble adhesion molecules and extraarticular manifestations: Meyer, Martin F. and Schmidt, Olga and Hellmich, Bernhard and Schatz, Helmut and Klein, Harald H. and Braun, Jürgen Google Scholar
Effect of linear polarized light irradiation near the stellate ganglion in skin blood flow of fingers in patients with progressive systemic sclerosis: Lee, Chih-Hung and Chen, Gwo-Shing and Yu, Hsin-Su Google Scholar
Correlation of severity of chronic venous disease with capillary morphology assessed by capillary microscopy: Howlader, Mohammad Hossain and Smith, Philip D. Coleridge Google Scholar
Proceedings from the 15th Annual Symposium of the London Hypertension Society, 25th May 2004: London, Charterhouse Square and Smithfield, West and EC, London Google Scholar
Laser Doppler anemometry distinguishes primary Raynaud phenomenon from VWF syndrome: Ziegler, Sophie and Gschwandtner, Michael and Zöch, Carina and Barth, Alfred and Minar, Erich and Rüdiger, Hugo and Osterode, Wolf Google Scholar
Impairment of cutaneous arteriolar 0.1 Hz vasomotion in diabetes: Meyer, M. F. and Rose, C. J. and Hülsmann, J. O. and Schatz, H. and Pfohl, M. Google Scholar
Sildenafil in the Treatment of Raynaud’s Phenomenon Resistant to Vasodilatory Therapy: Kaveh Shariat https://www.researchgate.net/publication/277761638
Impaired microcirculation after subarachnoid hemorrhage in an in vivo animal model: Kuo-Chuan Wang 1 , Sung-Chun Tang 2 , Jing-Er Lee 3 , Jui-Chang Tsai 1 , Dar-Ming Lai 1 , Wei-Chou Lin 5 , Chih-Peng Lin 6 , Yong-Kwang Tu 1 & Sung-Tsang Hsieh Scientific Reports (2018) 8:13315 DOI:10.1038/s41598-018-31709-7
Effects of Candesartan versus Amlodipine on Capillary Rarefaction, Pulse Wave Velocity and Central Blood Pressure in Patients with Essential Hypertension: Rajendra P Raghuraman, Christine Carney, Helen Mullahy, Oluwabusola Ogunseitan, Duolao Wang and Tarek F Antonios J Non Invasive Vasc Invest 2: 008 http://dx.doi.org/10.24966/NIVI-7400/100008

VCS / HVCS Nailfold

Rarefaction of skin capillaries in patients with anginal chest pain and normal coronary arteriograms.: T. F. T. Antonios 1, J. C. Kaski 2, K. M. Hasan 1, S.J. Brown 2 and D.R.J. Singer 1. European Heart Journal (2001) 22, 1144-1148 See
Quantitative outcome measures for systemic sclerosis-related Microangiopathy–Reliability of image acquisition in Nailfold Capillaroscopy: Dinsdale, Graham and Moore, Tonia and O’Leary, Neil and Berks, Michael and Roberts, Christopher and Manning, Joanne and Allen, John and Anderson, Marina and Cutolo, Maurizio and Hesselstrand, Roger and others, Google Scholar
Intra-and inter-observer reliability of nailfold videocapillaroscopy - A possible outcome measure for systemic sclerosis-related microangiopathy: Dinsdale, Graham and Moore, Tonia L. and O’Leary, Neil and Tresadern, Philip and Berks, Michael and Roberts, Christopher and Manning, Joanne B. and Allen, John and Anderson, Marina and Cutolo, Maurizio and Hesselstrand, Roger and Howell, Kevin and Pizzorni, Carmen and Smith, Vanessa and Sulli, Alberto and Wildt, Marie and Taylor, Christopher and Murray, Andrea and Herrick, Ariane L. DOI Link URL Link Google Scholar
Quantification of differences between nailfold capillaroscopy images with a scleroderma pattern and normal pattern using measures of geometric and algorithmic complexity: Urwin, Samuel George and Griffiths, Bridget and Allen, John Google Scholar
Type 2 diabetes mellitus and hyperglycaemia are associated with microvascular dysfunction: the Maastricht Study: Muris, Dennis MJ and Houben, Alfons JHM and Karaça, Ümit and Schaper, Nicolaas C. and Henry, Ronald MA and van der Kallen, Carla JH and Sep, Simone JS and Koster, Annemarie and Dagnelie, Pieter C. and Stehouwer, Coen DA and others, Google Scholar
Uric acid and skin microvascular function: the Maastricht study: Wijnands, José MA and Houben, Alfons JHM and Muris, Dennis MJ and Boonen, Annelies and Schram, Miranda T. and Sep, Simone JS and van der Kallen, Carla JH and Henry, Ronald MA and Dagnelie, Pieter C. and van der Linden, Sjef and others, Google Scholar
GLP-1 receptor agonist exenatide increases capillary perfusion independent of nitric oxide in healthy overweight men: Smits, Mark M. and Muskiet, Marcel HA and Tonneijck, Lennart and Kramer, Mark HH and Diamant, Michaela and van Raalte, Daniël H. and Serné, Erik H. DOI Link Google Scholar
The influence of measurement location on reliability of quantitative nailfold videocapillaroscopy in patients with SSc: Murray, Andrea K. and Vail, Andy and Moore, Tonia L. and Manning, Joanne B. and Taylor, Christopher J. and Herrick, Ariane L. Google Scholar

CapiScope

Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII: McGown, Caroline C. and Brookes, Zoë LS and Hellewell, Paul G. and Ross, Jonathan J. and Brown, Nicola J. Google Scholar
Capillary remodeling in infants born to hypertensive pregnancy: pilot study: Antonios, Tarek FT and Raghuraman, Rajendra P. and D’souza, Rohan and Nathan, Preetha and Wang, Duolao and Manyonda, Isaac T. Google Scholar
The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF-and VEGF-receptor, are liver-size-dependent after partial hepatectomy in rats: Deng, Meihong and Huang, Hai and Jin, Hao and Dirsch, Olaf and Dahmen, Uta Google Scholar
Hepatic arterial perfusion is essential for the spontaneous recovery from focal hepatic venous outflow obstruction in rats: Huang, H. and Deng, M. and Jin, H. and Liu, A. and Dirsch, O. and Dahmen, U. Google Scholar
Fetal Programming: D’Souza, Rohan and Raghuraman, Rajendra P. and Nathan, Preetha and Manyonda, Isaac T. and Antonios, Tarek FT Google Scholar
Multiple different laminar velocity profiles in separate veins in the microvascular network of brain cortex in rats: Mutalifu, Yalikun and Holm, Lovisa and Ince, Can and Theodorsson, Elvar and Sjöberg, Folke Google Scholar
Effect and risk of AEE788, a dual tyrosine kinase inhibitor, on regeneration in a rat liver resection model: Deng, M. and Huang, H. and Dirsch, O. and Dahmen, U. Google Scholar
Macromolecular leak from extrasplenic lymphatics during endotoxemia: Brookes, Zoë LS and Mansart, Arnaud and McGown, Caroline C. and Ross, Jonathan J. and Reilly, Charles S. and Brown, Nicola J. Google Scholar
Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo: Brookes, Zoë LS and Kaufman, Susan Google Scholar
Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo: Brookes, Z. L. and Reilly, C. S. and Brown, N. J. Google Scholar
The dose-dependent effects of fentanyl on rat skeletal muscle microcirculation in vivo: Brookes, Zoë LS and Brown, Nicola J. and Reilly, Charles S. Google Scholar
Microcirculation in meningococcal septic shock: Top, Anke PC and de Meij, Neelke and van Velzen, Joella E. and Ince, Can and Tibboel, Dick Google Scholar
Extracorporeal membrane oxygenation preserves the microcirculation in neonates with severe respiratory failure: Top, Anke PC and Buijs, Erik AB and Schouwenberg, Patrick HM and others, Google Scholar

OPS CapiScope

VALIDATION OF AN ANALYSIS SOFTWARE FOR INTRAVITAL MICROSCOPY WITH OPS IMAGING APPLIED TO THE HAMSTER SKINFOLD CHAMBER B.: Dadasch , A. G. Harris , K. R. Kellam, F. Christ 7th World Congress for Microcirculation 19-22 August 2001 Sydney, Australia See
VALIDATION OF AN ANALYSIS SOFTWARE FOR OPS-IMAGING USED IN HUMANS: S.Schaudig , B.Dadasch , K.R. Kellam, F. Christ 7th World Congress for Microcirculation 19-22 August 2001 Sydney, Australia See
Capillary remodeling in infants born to hypertensive pregnancy: pilot study: Antonios, Tarek FT and Raghuraman, Rajendra P. and D’souza, Rohan and Nathan, Preetha and Wang, Duolao and Manyonda, Isaac T. Google Scholar
The anti-proliferative side effects of AEE788, a tyrosine kinase inhibitor blocking both EGF-and VEGF-receptor, are liver-size-dependent after partial hepatectomy in rats: Deng, Meihong and Huang, Hai and Jin, Hao and Dirsch, Olaf and Dahmen, Uta Google Scholar
Hepatic arterial perfusion is essential for the spontaneous recovery from focal hepatic venous outflow obstruction in rats: Huang, H. and Deng, M. and Jin, H. and Liu, A. and Dirsch, O. and Dahmen, U. Google Scholar
Fetal Programming: D’Souza, Rohan and Raghuraman, Rajendra P. and Nathan, Preetha and Manyonda, Isaac T. and Antonios, Tarek FT Google Scholar
Multiple different laminar velocity profiles in separate veins in the microvascular network of brain cortex in rats: Mutalifu, Yalikun and Holm, Lovisa and Ince, Can and Theodorsson, Elvar and Sjöberg, Folke Google Scholar
Effect and risk of AEE788, a dual tyrosine kinase inhibitor, on regeneration in a rat liver resection model: Deng, M. and Huang, H. and Dirsch, O. and Dahmen, U. Google Scholar
Microcirculation in meningococcal septic shock: Top, Anke PC and de Meij, Neelke and van Velzen, Joella E. and Ince, Can and Tibboel, Dick Google Scholar
Extracorporeal membrane oxygenation preserves the microcirculation in neonates with severe respiratory failure: Top, Anke PC and Buijs, Erik AB and Schouwenberg, Patrick HM and others, Google Scholar
Functional Vessel Density in the First Month of Life in Preterm Neonates: JULIA KROTH, KATHRIN WEIDLICH, STEPHAN HIEDL, CLAUDIA NUSSBAUM, FRANK CHRIST, AND ORSOLYA GENZEL-BOROVICZÉNY Pediatr Res 64: 567–571, 2008 0031-3998/08/6405-0567

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